Interactions between grapefruit juice and cardiovascular drugs. Squirt Squirt Ruby Red Naturally Flavored Citrus Soda, 20 fl oz (4.9) 7 reviews 9.38 46.Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects.Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice.The FDA-approved prescribing information for Lipitor does warn about a grapefruit juice interaction, but only when consuming very large amounts (1.2 liters of juice!): References Nevertheless, other studies theorize that only large amounts of grapefruit consumption would cause a clinically significant interaction, and this may be the case with Lipitor specifically. In terms of the actual juice, some studies have shown that less than one cup (~240 mL) of 100% grapefruit juice can cause an interaction. Squirt has been around since the late ‘30s, but didn’t make it to Mexico until 1955.
Several sources report eating as little as one grapefruit can cause issues. English’s research into the murky history of the drink, it appears that the most likely origin of the Paloma was that it evolved naturally following the invention of Squirt grapefruit soda. However, how much grapefruit juice one needs to consume to produce a clinically significant drug interaction isn't entirely known.
It has been fairly well documented that grapefruit juice can interact with several drugs, including Lipitor ( atorvastatin), a 'statin' medication used to lower cholesterol.
Studies offer conflicting data on just how much grapefruit it takes to produce a clinically significant interaction.
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